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REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1450603

Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression

Provisionally accepted
Yuchao Tang Yuchao Tang 1Tingting Shi Tingting Shi 1Shu Lin Shu Lin 1,2*Taiyong Fang Taiyong Fang 1*
  • 1 The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
  • 2 Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

The final, formatted version of the article will be published soon.

    Esophageal carcinoma (EC) is one of the most common tumors in China and seriously affects patient survival and quality of life. In recent years, increasing studies have shown that the tumor microenvironment is crucial in promoting tumor progression and metastasis. Tumor-associated macrophages (TAM) are key components of the tumor immune microenvironment and promote both tumor growth and antitumor immunity. Much evidence suggests that TAMs are closely associated with esophageal tumors. However, understanding of the clinical value and mechanism of action of TAM in esophageal cancer remains limited. Therefore, we reviewed the status of research on the role and mechanism of action of TAM in EC progression and summarized its potential clinical application value to provide a theoretical basis for the clinical treatment of EC.

    Keywords: Tumor-associated macrophages, Esophageal carcinoma, Tumor Microenvironment, Mechanism, Clinical treatment

    Received: 17 Jun 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Tang, Shi, Lin and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shu Lin, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
    Taiyong Fang, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.