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CASE REPORT article

Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1449945

Castleman disease variant of POEMS syndrome without M protein: a case report

Provisionally accepted
Min Ji Min Ji Shumin Jin Shumin Jin Shaolei Zang Shaolei Zang Peng Li Peng Li Fei Lu Fei Lu Chuanli Zhao Chuanli Zhao Chunqing Zhang Chunqing Zhang Chunyan Ji Chunyan Ji Jingjing Ye Jingjing Ye *
  • Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

The final, formatted version of the article will be published soon.

    POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome is an paraneoplastic syndrome associated with an underlying plasma cell neoplasm.According to the current diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy and clonal plasma cell disorder are required for diagnosis. We report a case of Castleman disease variant of POEMS syndrome without monoclonal protein (M protein) expression, which presented with polyneuropathy, organomegaly, endocrinopathy, skin lesions, as well as sclerotic bone lesions. The patient was treated with lenalidomide and dexamethasone (RD), after which her symptoms improved. The fingings in this case suggest that the diagnostic criteria for POEMS syndrome may be required reconsideration.

    Keywords: POEMS syndrome1, Castleman disease2, monoclonal protein3, diagnostic criteria4, Case report5

    Received: 16 Jun 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Ji, Jin, Zang, Li, Lu, Zhao, Zhang, Ji and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jingjing Ye, Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

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