Zhipeng Jin
Guo Tianyu
Xue Zhang
Xin Wang
*
Yefu Liu
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1448695
PTK7: An Underestimated Contributor to Human Cancer
Provisionally accepted- Liaoning Cancer Hospital & Institute, Shenyang, China
Protein tyrosine kinase 7 (PTK7) is an evolutionarily conserved transmembrane receptor and a specialized tyrosine kinase protein lacking kinase activity. PTK7 has been found to be strongly associated with a variety of diseases, including cancer. In this review, we will provide a comprehensive overview of the involvement of PTK7 in human cancer, focusing on the changing research landscape of PTK7 in cancer research, the molecular mechanisms of PTK7 involved in cancer progression, the targetability of PTK7 in cancer therapy, and the potential application of PTK7 in cancer management, thus demonstrating that PTK7 may be an underestimated contributor to human cancer.
Keywords: PTK7, Cancer, biomarker, prognosis, Anti-cancer therapy, diagnosis
Received: 13 Jun 2024; Accepted: 23 Sep 2024.
Copyright: © 2024 Jin, Tianyu, Zhang, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xin Wang, Liaoning Cancer Hospital & Institute, Shenyang, China
Yefu Liu, Liaoning Cancer Hospital & Institute, Shenyang, China
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