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CASE REPORT article

Front. Oncol.
Sec. Radiation Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1448593

Delayed Neurotoxicity in HER2-Positive Breast Cancer: A Case Series on Combined SRS and T-DM1 Treatment

Provisionally accepted
Menekse Turna Menekse Turna *Hale B. Caglar Hale B. Caglar
  • Anadolu Medical Center, Istanbul, Türkiye

The final, formatted version of the article will be published soon.

    This case series presents four instances of late neurotoxicity observed in HER2positive breast cancer patients with brain metastases following treatment with stereotactic radiosurgery (SRS) and subsequent trastuzumab emtansine (T-DM1) therapy. Despite initial control of intracranial disease, patients experienced neurological deterioration months to years post-treatment. Radiological assessments revealed distinct patterns consistent with radiation necrosis, particularly in areas previously treated with SRS and subsequent T-DM1 administration. These changes, characterized by enlarging cystic masses with hemorrhagic components, emphasize the importance of vigilant monitoring in patients undergoing combined SRS and T-DM1 therapy for brain metastatic breast cancer.This report underscores the need for further investigation into the long-term effects of combining SRS with novel systemic therapies, particularly in HER2-positive breast cancer patients with brain metastases. Understanding and mitigating late neurotoxicity are critical for optimizing treatment strategies and improving patient outcomes.

    Keywords: Her-2 breast cancer, stereotactic radiotherapy, brain metastasis, Trastuzumab emtansine, radionecrosis

    Received: 13 Jun 2024; Accepted: 11 Sep 2024.

    Copyright: © 2024 Turna and Caglar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Menekse Turna, Anadolu Medical Center, Istanbul, Türkiye

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.