Chengsen Cai
*
Jun Wang
*The final, formatted version of the article will be published soon.
CASE REPORT article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1448219
This article is part of the Research Topic Precision Medical Imaging for Cancer Diagnosis and Treatment - Vol. II View all 27 articles
Primary Hepatoid Adenocarcinoma of the Lung with Extremely Elevated Serum AFP: A Case Report and Literature Review
Provisionally accepted- Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Primary hepatoid adenocarcinoma of the lung (HAL) is an exceptionally rare subtype of lung cancer that mimics the morphology and biological behavior of hepatocellular carcinoma. Although reports in the literature are limited, HAL is known for its high malignancy and poor prognosis and is thus drawing increasing attention. We present the case of a patient with a mass-like consolidation with central necrosis initially misdiagnosed as inflammation at another medical institution despite a percutaneous lung biopsy. After ineffective anti-inflammatory treatment, she was referred to our hospital. We performed another lung biopsy, obtaining five samples from different angles, and eventually diagnosed her with HAL. Surprisingly, her serum alpha-fetoprotein (AFP) levels were extraordinarily high, leading to the successful diagnosis of HAL. Here, we present the case report and a related literature review.
Keywords: AFP, Primary Hepatoid Adenocarcinoma, Lung biopsy, Immunohistochemical, chemotherapy
Received: 12 Jun 2024; Accepted: 30 Aug 2024.
Copyright: © 2024 Cai, Zhang, Wang, Zhao, Zhang, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chengsen Cai, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Ningxin Zhang, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Lianzhong Wang, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Haisu Zhao, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Xiaoye Zhang, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Bin Li, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Jun Wang, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
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