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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1447903

Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Cancer Patients Undergoing Neck Dissection Insights from a Large Cohort Study

Provisionally accepted
Shuping Wu Shuping Wu 1,2Yu Liu Yu Liu 1Xianhui Ruan Xianhui Ruan 1Xiangqian Zheng Xiangqian Zheng 1*
  • 1 Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
  • 2 Fujian Provincial Cancer Hospital, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Background: This study aimed to investigate the risk factors and metastatic patterns in papillary thyroid cancer (PTC) patients undergoing lymph node dissection, offering guidance for clinical practice.Methods:A total of 924 PTC patients who underwent thyroidectomy with central neck dissection (CND) or lateral neck dissection (LND) between January 2021 and November 2022 were included in the analysis. The study investigated the relationships between clinicopathological characteristics, lymph node metastasis, and various risk factor.Results:Among the 924 PTC patients, the cervical lymph node metastasis rate was 59.1% (546 patients). Of these patients, 381 had central neck metastasis (CNM, 41.2%), while the remaining 165 patients had lateral neck metastasis (LNM, 17.9%,). Factors associated with increased risk of CNM and LNM included larger tumor diameter, presence of multiple tumors, and capsular invasion (p<0.05). Male sex, age <55 years, larger tumor diameter (>0.85 cm), multiple tumors, capsular invasion, and absence of Hashimoto's disease were identified as independent risk factors for CNM (p<0.05), with an AUC value of 0.722. CNM, maximum diameter >1.15 cm, and multiple tumors were independent risk factors for LNM (p<0.05), with an AUC of 0.699. Conclusion:These findings suggest that tailored neck dissection based on individual risk factors is crucial, particularly in cases of suspected LNM with larger tumors, CNM, multiple tumors, and capsular invasion.

    Keywords: Risk factors, Neck Dissection, Lymph Node, metastasis, thyroid cancer

    Received: 12 Jun 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Wu, Liu, Ruan and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiangqian Zheng, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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