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MINI REVIEW article

Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1447509

ABHD5 as a friend or an enemy in cancer biology?

Provisionally accepted
Jianya Cai Jianya Cai 1Hongwei Cheng Hongwei Cheng 2*Shuangta Xu Shuangta Xu 3*
  • 1 Quanzhou Medical College, Quanzhou, Fujian Province, China
  • 2 Zhuhai UM Science & Technology Research Institute, University of Macau, Macau SAR, China
  • 3 The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

The final, formatted version of the article will be published soon.

    Alpha beta hydrolase domain containing 5 (ABHD5) is an essential coactivator of adipose triglyceride lipase (ATGL), a rate-limiting enzyme in various cell types that promotes the hydrolysis of triacylglycerol (TG) into diacylglycerol (DG) and fatty acid (FA). It acts as a critical regulatory factor in cellular lipid metabolism. The reprogramming of lipid metabolism is one of the hallmarks of cancer, suggesting that altering lipid metabolism could become a new strategy for tumor treatment.Research has revealed a close association between ABHD5 and the development and progression of malignancies. This review summarizes the role of ABHD5 in various malignant tumors and explores the different signaling pathways and metabolic routes that may be involved, providing a comprehensive mechanistic understanding of ABHD5.

    Keywords: ABHD5, Lipid Metabolism, proliferation, invasion, oncogene

    Received: 11 Jun 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Cai, Cheng and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hongwei Cheng, Zhuhai UM Science & Technology Research Institute, University of Macau, Macau SAR, China
    Shuangta Xu, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.