Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1446736
This article is part of the Research Topic Quantitative Imaging: Revolutionizing Cancer Management with biological sensitivity, specificity, and AI integration View all 18 articles

Assessment of synthetic MRI to distinguish Warthin's tumor from pleomorphic adenoma in the parotid gland: comparison of two methods of positioning the region of interest for synthetic relaxometry measurement

Provisionally accepted
Jiabin Sun Jiabin Sun 1*Xinping Kuai Xinping Kuai 2Danwei Huang Danwei Huang 3*Chuanhai Jia Chuanhai Jia 1*Shengyu Wang Shengyu Wang 4*
  • 1 Changshu No. 2 Peoples’ Hospital, Changshu, Jiangsu Province, China
  • 2 Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China
  • 3 Changzhou No.2 People's Hospital, Changzhou, Jiangsu Province, China
  • 4 Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Purpose: To assess the diagnostic potential of the synthetic MRI (SyMRI) for differentiating Warthin's tumors (WT) from pleomorphic adenomas (PA).Forty-nine individuals with parotid gland tumors (PA, n = 23; WT, n = 26) were recruited. Using two distinct regions of interest (ROI), SyMRI quantitative parameters of lesions were calculated, including mean and standard deviation (T1, T2, PD, T1sd, T2sd, and PDsd). Meanwhile, T1ratio, T2ratio, and PDratio (lesion/masseter muscle) were calculated based on the mean SyMRI quantitative parameters of masseter muscle (T1, T2, PD). Using the independent samples t test, we compared PA and WT parameters, while comparing the areas under the curve (AUC) using the DeLong's test. A multi-parameter SyMRI model was constructed using logistic regression analysis.In PA, the T1, T1sd, T2, PD, T1ratio, T2ratio, and PDratio derived from full and partial lesion ROIs were significantly higher than in WT. According to the receiver operating curve analysis, the AUC of the quantitative parameters derived from full-lesion and partiallesion ROIs ranged from 0.722 to 0.983 for differentiating PA from WT. T1 values derived from partial-lesion ROI delineation demonstrated the best diagnostic performance among all single parameters, achieving an AUC of 0.983. Using 1322 ms as a cutoff value, the sensitivity, specificity, and accuracy were 88.46%, 100% and 93.88%, respectively.The SyMRI-derived quantitative parameters demonstrated excellent performance for discriminating PA from WT in the parotid gland.

    Keywords: Parotid Neoplasms, Pleomorphic Adenomas, Warthin's tumor, Magnetic Resonance Imaging, Synthetic MRI, MAGnetic resonance image Compilation

    Received: 10 Jun 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Sun, Kuai, Huang, Jia and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiabin Sun, Changshu No. 2 Peoples’ Hospital, Changshu, Jiangsu Province, China
    Danwei Huang, Changzhou No.2 People's Hospital, Changzhou, Jiangsu Province, China
    Chuanhai Jia, Changshu No. 2 Peoples’ Hospital, Changshu, Jiangsu Province, China
    Shengyu Wang, Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.