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REVIEW article

Front. Oncol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1446328

Lonicerae Japonicae Flos with the homology of medicine and food: A review of TCM theory, active ingredients, anticancer mechanisms and clinical applications

Provisionally accepted
Ping Ma Ping Ma 1Ling Yuan Ling Yuan 2Shumin Jia Shumin Jia 3*Ziying Zhou Ziying Zhou 1Duojie Xu Duojie Xu 3Shicong Huang Shicong Huang 3*Fandi Meng Fandi Meng 3zhe Zhang zhe Zhang 4*Yi Nan Yi Nan 5*
  • 1 General Hospital of Ningxia Medical University, Yinchuan, China
  • 2 School of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
  • 3 Ningxia Medical University, Yinchuan, Ningxia, China
  • 4 China-Japan Friendship Hospital, Beijing, Beijing Municipality, China
  • 5 College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Region, China

The final, formatted version of the article will be published soon.

    Lonicerae Japonicae Flos (LJF, called Jinyinhua in China), comes from the dried flower buds or flowers to be opened of Lonicera japonica Thunb. in the Lonicera family. It has a long history of medicinal use and has a wide range of application prospects. As modern research advances, an increasing number of scientific experiments have demonstrated the anticancer potential of LJF.However, there is a notable absence of systematic reports detailing the anti-tumor effects of LJF. This review integrates the principles of Traditional Chinese Medicine (TCM) with contemporary pharmacological techniques, drawing upon literature from authoritative databases such as PubMed, CNKI, and WanFang to conduct a comprehensive study of LJF. Notably, a total of 507 compounds have been isolated and characterized from the plant to date, which include volatile oils, organic acids, flavonoids, iridoids, triterpenes and triterpenoid saponins. Pharmacological studies have demonstrated that LJF extract, along with components such as chlorogenic acid, luteolin, rutin, luteoloside, hyperoside and isochlorogenic acid, exhibits potential anticancer activities. Consequently, we have conducted a comprehensive review and summary of the mechanisms of action and clinical applications of these components. Furthermore, we have detailed the pharmacokinetics, quality control, and toxicity of LJF, while also discussing its prospective applications in the fields of biomedicine and preventive healthcare. It is hoped that these studies will provide valuable reference for the clinical research, development, and application of LJF.

    Keywords: Lonicerae Japonicae Flos, Antitumor mechanism, Homology of medicine and food, clinical application, Active ingredients

    Received: 09 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Ma, Yuan, Jia, Zhou, Xu, Huang, Meng, Zhang and Nan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shumin Jia, Ningxia Medical University, Yinchuan, 750004, Ningxia, China
    Shicong Huang, Ningxia Medical University, Yinchuan, 750004, Ningxia, China
    zhe Zhang, China-Japan Friendship Hospital, Beijing, 100029, Beijing Municipality, China
    Yi Nan, College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Region, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.