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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Metabolism
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1446310
This article is part of the Research Topic Metabolism, Gut Microbiome, and Cancer View all articles

Genetic Effect of Basal Metabolic Rate on the Benign Neoplasm of Bone and Articular Cartilage: A Mendelian Randomization Study

Provisionally accepted
Guijin Huang Guijin Huang Ying Yao Ying Yao Lin Fan Lin Fan Sisi Li Sisi Li *
  • Stomatological Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Background: Previous studies have found an association between basal metabolic rate (BMR) and various malignant neoplasms, including bone tumors. BMR is also associated with bone mineral density, but the causality between BMR and benign neoplasms of bone and articular cartilage remains uncertain.Design: Single nucleotide polymorphisms (SNPs) associated with BMR (p < 5 × 10⁻⁸) were used as instrumental variables for Mendelian randomization 1 analysis of neoplasm risk. The inverse variance weighted (IVW) method was the primary approach, with the weighted median and MR-Egger regression serving as supplements.Results: In this MR analysis, the IVW method supported a causal relationship between BMR and benign neoplasms of bone and articular cartilage (OR = 1.417; 95% CI, 1.039 to 1.930; p = 0.027).No evidence of heterogeneity or pleiotropy in the selected SNPs was found in our study. Thus, based on these results, we discovered a possible causal relationship between BMR and benign neoplasms of bone and articular cartilage.In this MR study, evidence suggested a genetic correlation between genetically predicted BMR and the risk of neoplasms in bone and articular cartilage.

    Keywords: basal metabolic rate, Benign neoplasm, Bone, articular cartilage, Mendelian randomization

    Received: 09 Jun 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Huang, Yao, Fan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sisi Li, Stomatological Hospital of Chongqing Medical University, Chongqing, China

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