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CASE REPORT article
Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1445668
Single Gene Testing and Comprehensive Genomic Profiling in Non-Small Cell Lung Cancer: A Case Series of Divergent Results from a Large Reference Laboratory
Provisionally accepted- 1 Labcorp Oncology, Durham, United States
- 2 Duke University Medical Center, Duke University, Durham, North Carolina, United States
- 3 Baptist Health System, San Antonio, Texas, United States
- 4 Fortrea Inc., Durham, North Carolina, United States
- 5 Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
- 6 Comprehensive Cancer Center, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, United States
Clinical management of non-small cell lung cancer (NSCLC) requires accurate identification of tumor-specific genetic alterations to inform treatment options. Historically, providers have relied on single-gene testing (SGT) for actionable variants due to a perception of cost-effectiveness and/or efficient turnaround time compared to next-generation sequencing (NGS). However, not all actionable variants may be evaluated through SGT modalities, and an SGT approach can exhaust valuable tissue needed for more comprehensive analyses. In contrast, comprehensive genomic profiling (CGP) tests employ NGS to sequence megabases of DNA and RNA to evaluate all relevant molecular alterations, providing a broader genetic profile to identify actionable alterations that SGT may not accurately or efficiently assess. Here, we briefly describe four cases from a large reference laboratory in which actionable alterations were identified by CGP but not SGT. The discussion highlights the utility and advantages of using CGP to provide complete and timely treatment options and clinical trial opportunities for patients with NSCLC.
Keywords: non-small cell lung cancer (NSCLC) molecular testing, single gene testing (SGT), Comprehensive genomic profiling (CGP), next-generation sequencing (NGS), Cancer genomics
Received: 07 Jun 2024; Accepted: 04 Oct 2024.
Copyright: © 2024 Strickland, Nesline, Previs, Ko, Cooper, Rushton, Wallen, Pabla, Conroy, Sausen, Saini, Cantini, Jensen, Caveney, Eisenberg, Severson and Ramkissoon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kyle C. Strickland, Labcorp Oncology, Durham, United States
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