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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1445375

Influence of diabetes on microbiome in prostate tissues of patients with prostate cancer

Provisionally accepted
Jin-Jae Lee Jin-Jae Lee 1Jung Kwon Kim Jung Kwon Kim 2Bumjo Oh Bumjo Oh 3Sung Kyu Hong Sung Kyu Hong 4,5Bong-Soo Kim Bong-Soo Kim 1*
  • 1 Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea
  • 2 Department of Urology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea
  • 3 Department of Family Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea
  • 4 Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea
  • 5 Department of Urology, Seoul National University Bundang Hospital, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Although microbiota in prostatic tissues of patients with prostate cancer have been studied, results of different studies have been inconsistent. Different ethnicity of study subjects, different study designs, and potential contaminations during sample collection and experiments might have influenced microbiome results of prostatic tissues. In this study, we analyzed microbiota and their potential functions in benign and malignant tissues of prostate cancer considering possible contaminants and host variables. A total of 118 tissue samples (59 benign tissues and 59 malignant tissues) obtained by robot-assisted laparoscopic radical prostatectomy were analyzed and 64 negative controls (from sampling to sequencing processes) were included to reduce potential contaminants. Alteration of the microbiome in prostate tissues was detected only in patients with diabetes. Furthermore, the influence of diabetes on microbiome was significant in malignant tissues. The microbiome in malignant tissues of patients with diabetes was influenced by pathologic stages. The relative abundance of Cutibacterium was reduced in the high pathologic group compared to that in the intermediate group. This reduction was related to microbial pathways increased in the high pathologic group. Results of this study indicate that diabetes can influence the progression of prostate cancer with microbiome alteration in prostate tissues. Although further studies are necessary to confirm findings of this study, this study can help us understand tissue microbiome in prostate cancer and improve clinical therapy strategies.

    Keywords: microbiome, prostate cancer, prostate tissue, diabetes, Pathologic group

    Received: 13 Jun 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Lee, Kim, Oh, Hong and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bong-Soo Kim, Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea

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