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CASE REPORT article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1444172
Ceftazidime/Avibactam Combined with Colistimethate Sodium Successfully Cures Carbapenem-resistant Pseudomonas Aeruginosa-induced Brain Abscess in a Child Post-craniotomy: a Case Report
Provisionally accepted- 1 Beijing Electric Power Hospital, Beijing, China
- 2 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
The treatment of brain abscess induced by carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a clinical challenge around the world. Apart from novel β-lactam/β-lactamase inhibitors and polymyxins, there are few sufficiently powerful antibiotics that are effective against CRPA-induced infections. Considering the blood-brain barrier factor, there are even fewer drugs that can be used to treat intracranial CRPA-induced infections. In this article, we reported a case of CRPA-induced brain abscess that was successfully treated with intravenous 2 / 14 ceftazidime/avibactam and intrathecal colistimethate sodium in a child after intracranial tumor resection.
Keywords: brain abcess, Central Nervous System Infections, Carbapenem-resistant Pseudomonas aeruginosa, Ceftazidime/avibactam, Colistimethate sodium
Received: 05 Jun 2024; Accepted: 03 Sep 2024.
Copyright: © 2024 Yuan, Zong, Ren, Zong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Miao Zong, Beijing Electric Power Hospital, Beijing, China
Cong Ren, Beijing Electric Power Hospital, Beijing, China
Wenjing Zong, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, Beijing Municipality, China
Zhongdong Li, Beijing Electric Power Hospital, Beijing, China
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