Skip to main content

CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1444172
This article is part of the Research Topic Clinical Therapy of Brain Tumors View all 14 articles

Ceftazidime/Avibactam Combined with Colistimethate Sodium Successfully Cures Carbapenem-resistant Pseudomonas Aeruginosa-induced Brain Abscess in a Child Post-craniotomy: a Case Report

Provisionally accepted
Minglu Yuan Minglu Yuan 1Miao Zong Miao Zong 1*Cong Ren Cong Ren 1*Wenjing Zong Wenjing Zong 2*Zhongdong Li Zhongdong Li 1*
  • 1 Beijing Electric Power Hospital, Beijing, China
  • 2 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    The treatment of brain abscess induced by carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a clinical challenge around the world. Apart from novel β-lactam/β-lactamase inhibitors and polymyxins, there are few sufficiently powerful antibiotics that are effective against CRPA-induced infections. Considering the blood-brain barrier factor, there are even fewer drugs that can be used to treat intracranial CRPA-induced infections. In this article, we reported a case of CRPA-induced brain abscess that was successfully treated with intravenous 2 / 14 ceftazidime/avibactam and intrathecal colistimethate sodium in a child after intracranial tumor resection.

    Keywords: brain abcess, Central Nervous System Infections, Carbapenem-resistant Pseudomonas aeruginosa, Ceftazidime/avibactam, Colistimethate sodium

    Received: 05 Jun 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Yuan, Zong, Ren, Zong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Miao Zong, Beijing Electric Power Hospital, Beijing, China
    Cong Ren, Beijing Electric Power Hospital, Beijing, China
    Wenjing Zong, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, Beijing Municipality, China
    Zhongdong Li, Beijing Electric Power Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.