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REVIEW article
Front. Oncol.
Sec. Pediatric Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1443256
This article is part of the Research Topic The Immunosuppressive Microenvironment in Pediatric Cancers: Applications and Considerations in Immunotherapy View all articles
Targeting the Ubiquitin-Proteasome System: A Novel Therapeutic Strategy for Neuroblastoma
Provisionally accepted- 1 Other, Dongguan, China
- 2 First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China
Neuroblastoma (NB) stands as a common and formidable malignant tumor among children, characterized by marked tumor heterogeneity and resistance to conventional treatments. Central to the regulation of protein stability, localization, and function is the process of ubiquitination-a critical protein modification. The therapeutic potential of drugs that target deubiquitination, demonstrated in the treatment of refractory multiple myeloma, warrants investigation in the context of NB. This review endeavors to demystify the intricate biological implications of ubiquitination within NB pathology, synthesize the current landscape of preclinical studies focused on the inhibition of the ubiquitin-proteasome system in NB, and assess the viability of this strategy as an innovative therapeutic frontier.
Keywords: Neuroblastoma, Ubiquitination, targeted therapy, cancer therapy, proteasome inhibition
Received: 03 Jun 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 He, Jiang, Wang, Xiao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yangshen He, Other, Dongguan, China
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