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REVIEW article

Front. Oncol.
Sec. Pediatric Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1443256
This article is part of the Research Topic The Immunosuppressive Microenvironment in Pediatric Cancers: Applications and Considerations in Immunotherapy View all articles

Targeting the Ubiquitin-Proteasome System: A Novel Therapeutic Strategy for Neuroblastoma

Provisionally accepted
Yangshen He Yangshen He 1*Zewei Jiang Zewei Jiang 2Jianing Wang Jianing Wang 2Tiantian Xiao Tiantian Xiao 1Jiaxin Wang Jiaxin Wang 2
  • 1 Other, Dongguan, China
  • 2 First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Neuroblastoma (NB) stands as a common and formidable malignant tumor among children, characterized by marked tumor heterogeneity and resistance to conventional treatments. Central to the regulation of protein stability, localization, and function is the process of ubiquitination-a critical protein modification. The therapeutic potential of drugs that target deubiquitination, demonstrated in the treatment of refractory multiple myeloma, warrants investigation in the context of NB. This review endeavors to demystify the intricate biological implications of ubiquitination within NB pathology, synthesize the current landscape of preclinical studies focused on the inhibition of the ubiquitin-proteasome system in NB, and assess the viability of this strategy as an innovative therapeutic frontier.

    Keywords: Neuroblastoma, Ubiquitination, targeted therapy, cancer therapy, proteasome inhibition

    Received: 03 Jun 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 He, Jiang, Wang, Xiao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yangshen He, Other, Dongguan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.