Skip to main content

SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1442612
This article is part of the Research Topic Advances in Brain Tumor Therapy View all 9 articles

A Systematic Review of Adult Pineoblastoma

Provisionally accepted
Xiufeng Chu Xiufeng Chu 1,2*Jixuan Xu Jixuan Xu 2Helen Benghiat Helen Benghiat 2
  • 1 Houston Methodist Research Institute, Houston, United States
  • 2 Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Background: Adult pineoblastoma is an extremely rare central nervous system malignancy. Limitations of tumour databases, single institution retrospective analyses and a few case reports are not sufficient to clarify treatment options.Therefore, a systematic review of comprehensive research data provides referenceable treatment options.Methods: A systematic review was performed using MEDLINE and Embase using the terms "pineoblastoma" and "adult." Relevant articles in the references were considered to supplement this systematic review. In addition, data were analysed using Kaplan-Meier survival curves, COX analysis, chi-square tests and log-rank tests.Results: A total of 108 adult cases from 32 articles were included in this study and the median age at diagnosis was 30 years. The 5-year survival rate was 49.5% (95% confidence interval: 0.378-0.602) and the 10-year survival rate was 33.9% (95% confidence interval: 0.207-0.476). During the 10-year follow-up period, Kaplan-Meier survival curves highlighted that the gross total resection was more beneficial than subtotal resection and no surgery (P=0.018). The treatment modality of radiotherapy and chemotherapy was beneficial for survival (P＜0.001; P=0.020). In addition, multivariate COX analysis showed that radiotherapy was an independent factor in the beneficial prognosis (P＜ 0.001) and gross total resection tends to improve survival within five years (P=0.079).For adult pineoblastoma, gross total excision and radiotherapy can be beneficial for survival.

    Keywords: Pineoblastoma, Adult, Surgery, Radiotherapy, chemotherapy, Survival

    Received: 02 Jun 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Chu, Xu and Benghiat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiufeng Chu, Houston Methodist Research Institute, Houston, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.