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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1441429

Meta-analysis of the Diagnostic Value of Exosomal microRNAs in Renal Cell Carcinoma

Provisionally accepted
Li Qingru Li Qingru 1Li Binyi Li Binyi 2*Tian Jing Tian Jing 3*Hong Liu Hong Liu 4*
  • 1 Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan, China
  • 2 Shenzhen Baoan Pure Traditional Chinese Medicine Treatment Hospital, Shenzhen, China
  • 3 Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
  • 4 Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Quick reading of articles: Evidence analysis of the diagnostic value of Exosomal miRNA in renal cell carcinoma ABSTRACT Aim: This meta-analysis aims to evaluate the potential of exosomal microRNAs(Exo-miRs) as diagnostic biomarkers for renal cell carcinoma(RCC). Methods: Clinical studies reporting the use of Exo-miRs in the diagnosis of RCC were retrieved from PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI),Wanfang, VIP, and Chinese Biomedical Literature Database (SinoMed). After relevant data were screened and extracted, the quality of the included studies was assessed using the QUADAS-2 tool. The Meta-disc (version 1.4) software was used to analyze the heterogeneity of threshold/non-threshold effects in the included studies. The Stata MP (version 16.0) software was used to calculate sensitivity(Sen), specificity(Spe), positive likelihood ratio(+LR), negative likelihood ratio(-LR), area under the curve(AUC), diagnostic odds ratio(DOR), and publication bias.Results: A total of 11 studies were included in this meta-analysis. Spearman correlation coefficient was 0.319 (P = 0.075; >0.05), indicating no threshold effects. The pooled Sen, Spe, +LR, -LR, DOR, and AUC were 0.73 (95% CI, 0.68-0.78), 0.81 (95% CI, 0.76-0.85), 3.80 (95% CI, 3.02-4.77), 0.33 (95% CI, 11.48 (95% CI,, and 0.84 (95% CI, 0.80-0.87), respectively. No publication bias was detected among the included studies.The expression of Exo-miRs plays an important role in the diagnosis of RCC. However, owing to the limited number of included studies and heterogeneity among them, further clinical research is necessary to verify the findings of this meta-analysis.

    Keywords: Exosomal microRNAs, Renal cell carcinoma, miRNA, Meta-analysis, diagnosis 1.Introduction Renal cell carcinoma (RCC), commonly known as kidney cancer, originates from renal tubular epithelial

    Received: 04 Jun 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Qingru, Binyi, Jing and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Li Binyi, Shenzhen Baoan Pure Traditional Chinese Medicine Treatment Hospital, Shenzhen, 518101, China
    Tian Jing, Henan University of Chinese Medicine, Zhengzhou, 450008, Henan Province, China
    Hong Liu, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.