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CASE REPORT article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1441083

Case report: Relapse of Intrathyroidal Parathyroid Carcinoma in Patient with novel MET and CDKN1C variants

Provisionally accepted
Ekaterina Kim Ekaterina Kim Anastasiia Lavreniuk Anastasiia Lavreniuk *Olga Spasskaya Olga Spasskaya Anna Eremkina Anna Eremkina Rustam Khalilovich Salimkhanov Rustam Khalilovich Salimkhanov Liliya Urusova Liliya Urusova Natalia Tarbaeva Natalia Tarbaeva Sergey Popov Sergey Popov Victoria Zakharova Victoria Zakharova Natalia Mokrysheva Natalia Mokrysheva
  • Endocrinology Research Center, Moscow, Russia

The final, formatted version of the article will be published soon.

    Parathyroid carcinoma (PC) is one of the rarest malignant neoplasms of the human endocrine system, with a prevalence of approximately 0.005% of all oncological diseases. Despite its indolent course, PC generally relapses in about 40-60% of cases. The severity of the disease is usually determined by uncontrolled life-threatening hypercalcemia. Currently, there are no reliable criteria for preoperative diagnosis of PC, moreover topical diagnosis and morphologic examination are still challenges. Surgery remains the gold standard for treatment of both primary tumors and distant metastases. Other treatment options such as chemotherapy or immunotherapy are limited. Targeted therapy is considered as a promising direction for disseminated tumors. We present a clinical case of a 70-year-old female patient with recurrent intrathyroidal PC and distant lung metastases with novel variants in the MET and CDKN1C genes.

    Keywords: primary hyperparathyroidism, Parathyroid cancer, metastases, Hypercalcemia, case report

    Received: 30 May 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Kim, Lavreniuk, Spasskaya, Eremkina, Salimkhanov, Urusova, Tarbaeva, Popov, Zakharova and Mokrysheva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anastasiia Lavreniuk, Endocrinology Research Center, Moscow, Russia

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