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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1441056
This article is part of the Research Topic Head and Neck Cancer in the Elderly - Vol II View all 4 articles

Indications for chemoradiotherapy in older patients with locally advanced head and neck cancer in Japan: a questionnaire survey in the JCOG Head and Neck Cancer Study Group

Provisionally accepted
Koichi Yasuda Koichi Yasuda 1Naomi Kiyota Naomi Kiyota 2*Kazuto Matsuura Kazuto Matsuura 3Satoshi Saito Satoshi Saito 4Yoshitaka Honma Yoshitaka Honma 5Yoshinori Imamura Yoshinori Imamura 6Kaoru Tanaka Kaoru Tanaka 7Sadamoto Zenda Sadamoto Zenda 8Takuma Onoe Takuma Onoe 9Takeshi Kodaira Takeshi Kodaira 10Satoshi Kobayashi Satoshi Kobayashi 11Hidefumi Aoyama Hidefumi Aoyama 12Nobuhiro Hanai Nobuhiro Hanai 13Akihiro Homma Akihiro Homma 14
  • 1 Department of Radiation Oncology, Hokkaido University Hospital, Sapporo, Japan
  • 2 Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan
  • 3 Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan
  • 4 Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka, Japan
  • 5 Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
  • 6 Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan
  • 7 Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan
  • 8 Department of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Kashiwa, Japan
  • 9 Division of Medical Oncology, Hyogo Cancer Center, Akashi, Japan
  • 10 Department of Radiation Oncology, Aichi Cancer Center Hospital, Aichi, Japan
  • 11 Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan
  • 12 Department of Radiation Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
  • 13 Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Aichi, Japan
  • 14 Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

The final, formatted version of the article will be published soon.

    Chemoradiation therapy (CRT) with concurrent high-dose cisplatin (CDDP) is one of the standard treatment options for locally advanced head and neck cancer. Since the indications specific to the older population have not been reported, we conducted a multicenter survey on the indications. The major factors influencing the indications for high-dose CDDP were renal function and performance status (PS). The majority agreed that the treatment is administered to patients aged 65–74 years with PS 0–1 and 65–74 years with eGFR ≥60 (ml/min/1.73m2), and not in patients aged ≥75 years with PS 2, ≥80 years with PS 1, and ≥65 years with eGFR <60. Regarding weekly CDDP, the majority agreed that the treatment is not conducted in patients aged ≥75 years with PS 2, ≥65 years with eGFR <40, and ≥70 years with eGFR <50. These results will help define the eligibility criteria for prospective studies on CRT in older patients.

    Keywords: older patients, head and neck cancer, Chemoradiotherapy, Radiotherapy, Cisplatin

    Received: 30 May 2024; Accepted: 12 Dec 2024.

    Copyright: © 2024 Yasuda, Kiyota, Matsuura, Saito, Honma, Imamura, Tanaka, Zenda, Onoe, Kodaira, Kobayashi, Aoyama, Hanai and Homma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Naomi Kiyota, Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan

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