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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1440246
This article is part of the Research Topic Management of Rare Oncological Cases View all 51 articles

Undifferentiated Endometrial Carcinoma Occurred During Perimenopausal Hormone Therapy: A Case Report and Literature Review

Provisionally accepted
Ying Wang Ying Wang Yu-Tong Zheng Yu-Tong Zheng Ling Zhang Ling Zhang Xue-Quan Cao Xue-Quan Cao Zhu Lin Zhu Lin Hong-Yu Liu Hong-Yu Liu Qiong-Ying Hu Qiong-Ying Hu *
  • Taizhou Central Hospital, Taizhou, China

The final, formatted version of the article will be published soon.

    Uterine corpus endometrial carcinoma, one of the three most frequent cancer of the female reproductive system, primarily affects women who are perimenopausal or postmenopausal. Moreover, it is an epithelial cancer that develops in the endometrium, which is classified as either estrogendependent (type-I) or non-estrogen-dependent (type-II). Non-estrogen-dependent endometrial cancers include plasma cell carcinoma, undifferentiated/dedifferentiated endometrial carcinoma and so on. Undifferentiated endometrial carcinoma is a rare but aggressive endometrial epithelial cancer that lacks of any histologic differentiation, and is classified as a high-grade endometrial cancer. This case presents that a patient had uterine corpus endometrial carcinoma during perimenopausal hormone therapy, and the patient was treated with sequential estrogen-progestin treatment for 3 years. During period she did not perform follow-up examination for the last 2 years due to the epidemic. Undifferentiated endometrial carcinoma is a special type of endometrial cancer that is not hormonedependent, and whether the occurrence of this case is related to perimenopausal hormone therapy needs to be verified by more evidence-based clinical cases and further studies.

    Keywords: UEC, Perimenopause, hormone, Curettage, ultrasound, MRI, Pathology

    Received: 29 May 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Wang, Zheng, Zhang, Cao, Lin, Liu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qiong-Ying Hu, Taizhou Central Hospital, Taizhou, China

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