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CASE REPORT article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1440119

Case report: a rare low-grade fumarate hydratase-deficient renal cell carcinoma

Provisionally accepted
Di Sun Di Sun Baohong Hu Baohong Hu Xinna Li Xinna Li Ping Yang Ping Yang *Guohua Yu Guohua Yu *
  • Yantai Yuhuangding Hospital, Yantai, China

The final, formatted version of the article will be published soon.

    Aim: To study and analyze the clinicopathological features of low-grade fumarate hydratase-deficient renal cell carcinoma in order to improve the understanding of the diagnosis and management of rare and specific morphological cases of this tumor. Methods: A case of low-grade FH-deficient renal cell carcinoma in a male is reported, and its clinicopathological features were analyzed and literature review was performed. Results: A 48-year-old middle-aged male with no relevant positive clinical signs was admitted to the hospital with an incidental finding of a mass in the lower pole of the left kidney during abdominal CT examination. Pathomorphology showed that the tumor cells were arranged in a variety of structures and the cells were low grade eosinophilic.Immunohistochemistry showed Pax-8 (+), Vim (partially +), FH (-), CK7 (-), CD117 (-), P504s (partially +), CD10 (partially +), CA-9 (-), TFE3 (partially +), SDHB (+), CK20 (-), and Ki-67 (+, about 2%). Final pathologic diagnosis: FH-deficient renal cell carcinoma (low grade). Conclusion:Single pure low-grade FH-deficient renal cell carcinoma of the kidney is extremely rare, and the image structure of this tumor exhibits diverse manifestations, which needs to be differentiated from many renal tumors in clinicopathological diagnosis in order to prevent misdiagnosis.

    Keywords: Renal cell carcinoma, FH-deficient, Low grade, case report, literature review

    Received: 29 May 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Sun, Hu, Li, Yang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ping Yang, Yantai Yuhuangding Hospital, Yantai, China
    Guohua Yu, Yantai Yuhuangding Hospital, Yantai, China

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