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REVIEW article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1439709

Integrin α2 in the microenvironment and the tumor compartment of digestive (gastrointestinal) cancers: emerging regulators and therapeutic opportunities

Provisionally accepted
Tiantian Liu Tiantian Liu 1,2Yanmei Gu Yanmei Gu 1,2Yuyu Zhang Yuyu Zhang 1,2Yumin Li Yumin Li 1,2*
  • 1 The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China
  • 2 Lanzhou University Second Hospital, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Integrins are a family of cell surface membrane receptors and play a crucial role in facilitating bidirectional cell signaling. Integrin α2 (ITGA2) is expressed across a range of cell types, including epithelial cells, platelets, megakaryocytes, and fibroblasts, where it functions as a surface marker and it is implicated in the cell movements. The most recent findings have indicated that ITAG2 has the potential to function as a novel regulatory factor in cancer, responsible for driving tumorigenesis, inducing chemoresistance, regulating genomic instability and remodeling tumor microenvironment. Hence, we primarily focus on elucidating the biological function and mechanism of ITGA2 within the digestive tumor microenvironment, while highlighting its prospective utilization as a therapeutic target for cancer therapy.

    Keywords: Integrin α2, Digestive cancers, chemoresistance, Genomic Instability, Tumor Microenvironment

    Received: 28 May 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Liu, Gu, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yumin Li, The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.