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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1436854
This article is part of the Research Topic Management of Rare Oncological Cases View all 28 articles

Ovarian mucinous tumor with a mural nodule of liposarcoma: a rare case

Provisionally accepted
Jiezhen Li Jiezhen Li 1Haijian huang Haijian huang 1*Qiang Zeng Qiang Zeng 2*Xin Chen Xin Chen 1*Lingfeng Chen Lingfeng Chen 1*
  • 1 Fujian Provincial Hospital, Fuzhou, Fujian Province, China
  • 2 First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Background: Ovarian mucinous tumor with a mural nodule is a rare and special type of ovarian surface epithelial-stromal tumor. Mural nodules are morphologically classified into three types: sarcoma-like, anaplastic carcinomatous, and true sarcomatous nodules. Ovarian mucinous tumors with true sarcomatous mural nodules are rare and challenging to diagnose, with only 10 cases reported worldwide. Currently, liposarcoma mural nodules remain unreported.A 91-year-old woman was hospitalized for postmenopausal vaginal bleeding for 3 weeks. Imaging revealed a large cystic mass (20.0 cm × 17.7 cm × 12.8 cm) on the right ovary. The mass was multilocular cystic, with a mural nodule (1.4 cm × 1.2 cm × 1.0 cm) in the focal cyst wall. Based on histological morphology, immunohistochemical staining, and MDM2/CDK4 fluorescence in situ hybridization testing, the diagnosis was ovarian mucinous cystadenoma with a mural nodule of welldifferentiated liposarcoma. To the best of our knowledge, this has never been reported before. High-throughput sequencing identified KRAS mutations in the ovarian mucinous cystadenoma. However, the liposarcoma mural nodule did not exhibit KRAS mutations but displayed copy number amplifications of CDK4 and DDR2, as well as a frameshift mutation in exon 13 of ASXL1 (p. A627Gfs*8). Conclusions: This case broadens the morphological spectrum of mural nodules in ovarian mucinous tumors, deepening our knowledge of this rare morphology. Meanwhile, through highthroughput sequencing, we found no overlapping genetic evidence between the liposarcoma mural nodule and associated ovarian mucinous cystadenoma.

    Keywords: Ovarian mucinous tumor, Mural nodule, Liposarcoma, Pathological feature, high-throughput sequencing

    Received: 22 May 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Li, huang, Zeng, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haijian huang, Fujian Provincial Hospital, Fuzhou, 350001, Fujian Province, China
    Qiang Zeng, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China
    Xin Chen, Fujian Provincial Hospital, Fuzhou, 350001, Fujian Province, China
    Lingfeng Chen, Fujian Provincial Hospital, Fuzhou, 350001, Fujian Province, China

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