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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1436009

[ 68 Ga]Ga-FAPI PET/CT in Brain Tumors: Comparison with [ 18 F]F-FDG PET/CT

Provisionally accepted
Ya Liu Ya Liu 1Haoyuan Ding Haoyuan Ding 1Jianpeng Cao Jianpeng Cao 2Guangfu Liu Guangfu Liu 1Yue Chen Yue Chen 1Zhanwen Huang Zhanwen Huang 1*
  • 1 The Affiliated Hospital of Southwest Medical University, Luzhou, China
  • 2 Second Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    To investigate the feasibility of [ 68 Ga]Ga-FAPI PET/CT in brain tumor imaging and to compare it with [ 18 F]F-FDG PET/CT. Methods: 25 patients with MRI-suspected brain tumors were included in the study. They underwent whole body [ 18 F]F-FDG PET/CT and [ 68 Ga]Ga-FAPI PET/CT and brain scans. The target-to-background ratio (TBR) of brain tumors was calculated with the background of surrounding normal brain tissues uptake. The SUVmax and TBR of [ 18 F]F-FDG PET/CT and [ 68 Ga]Ga-FAPI PET/CT were compared. Additionally, the correlation between the uptake of the tracer by lesions with the greatest diameter of the lesion, the breadth of the oedema band, and the enhancement scores of the MRI enhancement scans was analysed.

    Keywords: PET/CT, 18F-FDG, 68Ga-FAPI, Brain, tumor

    Received: 21 May 2024; Accepted: 23 Aug 2024.

    Copyright: © 2024 Liu, Ding, Cao, Liu, Chen and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhanwen Huang, The Affiliated Hospital of Southwest Medical University, Luzhou, China

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