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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Genetics
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1435605
The mutated in colorectal cancer (MCC) gene can serve as a potential biomarker of glioblastoma
Provisionally accepted- 1 School of Medicine, Chungnam National University, Daejeon, Republic of Korea
- 2 Yonsei University, Seoul, Seoul, Republic of Korea
The mutated in colorectal cancer (MCC) gene was initially identified as a candidate tumor suppressor gene in colorectal cancer, acting as a negative regulator of cell cycle progression.However, its functional roles in brain tumors, particularly glioblastoma, remains largely unexplored. This study reveals a significant association between MCC status and glioblastoma.In vitro analyses revealed elevated protein and mRNA levels of MCC in several glioblastoma cell lines (U118MG and T98G). Silencing MCC expression via siRNA-mediated knockdown resulted in increased proliferation and migration of these cell lines. Supporting these findings, analyses of The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Genotype-Tissue Expression (GTEx) databases confirmed higher MCC expression in glioblastoma tumors than in normal brain tissue. Importantly, we observed that high MCC expression was associated with poor prognosis in glioblastoma patients, highlighting its potential role in disease progression. Additionally, this study identifies a nuclear localization of MCC in the glioblastoma cell line. Collectively, these findings indicate that MCC expression is significantly upregulated in glioblastoma and may play a role in its pathophysiology, warranting further investigation.
Keywords: MCC, Glioblastoma, Cancer, biomarker, Brain
Received: 20 May 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 Nguyen, Juang, Gwon, Jung, Huang, Lee, Lee, Kwon, Park and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jongsun Park, School of Medicine, Chungnam National University, Daejeon, Republic of Korea
Seon-Hwan Kim, School of Medicine, Chungnam National University, Daejeon, Republic of Korea
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