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REVIEW article

Front. Oncol.
Sec. Breast Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1435421

An Overview of Invasive Micropapillary Carcinoma of the Breast: Past, Present, and Future

Provisionally accepted
Pu Qiu Pu Qiu 1,2Qiuxia Cui Qiuxia Cui 3Shengchao Huang Shengchao Huang 2Yuan q. Zhang Yuan q. Zhang 2*Haitao Zhang Haitao Zhang 1*Hui Luo Hui Luo 1*
  • 1 Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong Province, China
  • 2 Department of Breast Surgery, Affiliated Hospital of Guangdong Medical University,, Zhanjiang, China
  • 3 Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer,Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China

The final, formatted version of the article will be published soon.

    Invasive micropapillary carcinoma of the breast (IMPC) exhibits a unique micropapillary structure and "inside-out" growth pattern. Despite its extremely low incidence, IMPC has attracted considerable attention owing to its poor prognosis.Since Siriaunkgul and Tavassoli first proposed the term IMPC in 1993 to describe its morphological characteristics, with tumor cell clusters arranged in a pseudopapillary structure within the glandular cavity, its diagnostic rate has substantially increased.Based on the in-depth study of IMPC, a more comprehensive understanding of its epidemiology, clinicopathological features, and diagnostic criteria has been achieved in recent years. The pathogenesis and specific therapeutic targets of IMPC remain unclear. However, numerous studies have delved into its high-risk biological behavior. This review discusses the opportunities and challenges associated with IMPC.

    Keywords: Breast, Invasive micropapillary carcinoma, Poor prognosis, opportunities, Challenges

    Received: 20 May 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Qiu, Cui, Huang, Zhang, Zhang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuan q. Zhang, Department of Breast Surgery, Affiliated Hospital of Guangdong Medical University,, Zhanjiang, China
    Haitao Zhang, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong Province, China
    Hui Luo, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.