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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1435398

Analysis of the therapeutic effect and influencing factors on unresectable gastric cancer treated with conversion therapy

Provisionally accepted
Saiyi Han Saiyi Han 1Shaoliang Han Shaoliang Han 2Jun Qian Jun Qian 1Mengfu Guo Mengfu Guo 1Jianping Fan Jianping Fan 1*
  • 1 The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, China
  • 2 Department of Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Background: Gastric cancer(GC) is one of the leading causes of cancer-related death in China, with the extensive development of conversion therapy, the treatment of advanced unresectable gastric cancer(AUGC) patients has ushered in a new dawn. This study aimed to analyze the efficacy of conversion therapy in AUGC patients and explored the relevant factors affecting the efficacy. Method: We collected gastric cancer patients received conversion therapy from this center and designed a retrospective study. Result: We collected relevant clinical data from 160 patients with AUGC. 120 patients who underwent routine R0 resection were identified as conversion cases. 25 patients (15.6%) achieved pCR, 92 patients (57.5%) achieved objective response rate (ORR), 140 patients (87.5%) achieved disease control rate (DCR), and 20 cases (12.5%) observed tumor progression. There were 86 patients achieved pathological downgrading, with a total downgrading rate of 53.8%. Among the 160 patients, 37 patients(23.1%) had postoperative complications of varying degrees. 72 patients (45.0%) had tumor recurrence/progression at the end of follow-up. The last chemotherapy and surgery (CST) (OR=1.046, 95% CI 1.013-1.081, P=0.006), tumor invasion (OR=32.096, 95% CI 5.091-202.349, P<0.001), distant metastasis (OR=7.050, 95% CI 1.888-26.323, P=0.004) were independent factors influencing the 2 efficacy of conversion therapy. Conclusion: Conversion therapy may have a good therapeutic efficacy for AUGC, and some clinical factors affect the efficacy response.

    Keywords: advanced unresectable gastric cancer, Conversion therapy, metastasis, Surgery, Survival, Gastrectomy, Chemothearpy

    Received: 20 May 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Han, Han, Qian, Guo and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jianping Fan, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.