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CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1434631

Pulmonary Alveolar Proteinosis Complicated by Lung Cancer with Favorable Prognosis: A Case Report and Literature Review

Provisionally accepted
Ying Wu Ying Wu 1,2Wenhui Guan Wenhui Guan 1,2Jiaxi Deng Jiaxi Deng 1,2Wenwei Mo Wenwei Mo 1,2Beini Xu Beini Xu 1,2Jiahao Zhang Jiahao Zhang 3Huixin Jiang Huixin Jiang 1,2Jie Liu Jie Liu 1,2Xinqing Lin Xinqing Lin 1,2*Chengzhi Zhou Chengzhi Zhou 1,2*
  • 1 State Key Laboratory of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
  • 2 Guangzhou Medical University, Guangzhou, Guangdong Province, China
  • 3 Sun Yat-sen University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    With the increasing incidence of lung cancer, the coexistence of pulmonary alveolar proteinosis (PAP) and lung cancer is becoming more common. However, the standard treatment protocols for patients with both conditions are still being explored. The conflict between the rapidly evolving therapeutic approaches for tumors and the limited treatment options for PAP presents a significant challenge for clinicians.Determining the optimal timing of treatment for both conditions to maximize patient benefit is a clinical conundrum. Here, we report a rare case of PAP complicated by lung adenocarcinoma, where interstitial lung changes worsened after neoadjuvant therapy but improved significantly following surgical resection of the lung adenocarcinoma. This case highlights the importance of prioritizing tumor treatment in patients with lung cancer complicated by PAP and examines the interplay between the two conditions, as well as potential therapeutic strategies.

    Keywords: lung cancer, Pulmonary Alveolar Proteinosis, Checkpoint inhibitor pneumonitis, Granulocyte-Macrophage Colony-Stimulating Factor, Immunotherapy

    Received: 18 May 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Wu, Guan, Deng, Mo, Xu, Zhang, Jiang, Liu, Lin and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xinqing Lin, State Key Laboratory of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
    Chengzhi Zhou, State Key Laboratory of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

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