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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1433505
This article is part of the Research Topic Treatment of Brain Metastases from Non-Small Cell Lung Cancer: Preclinical, Clinical, and Translational Research View all 11 articles

Impact of Lung Adenocarcinoma Subtypes on Survival and Timing of Brain Metastases

Provisionally accepted
Chuyan Zhou Chuyan Zhou 1Xiaofang Zhang Xiaofang Zhang 1Xingyu Yan Xingyu Yan 1Haitao Xie Haitao Xie 1Hao Tan Hao Tan 1Yingqiu Song Yingqiu Song 1Mo Li Mo Li 1Yi Jin Yi Jin 1Tianlu Wang Tianlu Wang 2*
  • 1 Liaoning Cancer Hospital, China Medical University, Shenyang, Liaoning Province, China
  • 2 Department of Endoscopy, Liaoning Cancer Hospital and Institute, Shenyang, China

The final, formatted version of the article will be published soon.

    Lung cancer is a devastating disease, with brain metastasis being one of the most common distant metastases of lung adenocarcinoma. This study aimed to investigate the prognostic characteristics of individuals with brain metastases originating from invasive lung adenocarcinoma of distinct pathological subtypes, providing a reference for the management of these patients. Methods: Clinical data from 156 patients with lung adenocarcinoma-derived brain metastases were collected, including age, sex, smoking status, Karnofsky Performance Status scores, pathological subtype, lymph node metastasis, tumor site, treatment mode, T stage, and N stage. Patients were classified into two groups (highly differentiated and poorly differentiated) based on their pathological subtypes. Propensity score matching was used to control for confounding factors. The prognostic value of pathological subtypes was assessed using Kaplan-Meier analysis and Cox proportional hazards regression modeling. Results:Kaplan-Meier analysis indicated that patients in the moderately to highly differentiated group had better prognoses. Multivariate analysis revealed that being in the poorly differentiated group was a risk factor for poorer prognosis. Thoracic tumor radiation therapy, chemotherapy, and surgery positively influenced the time interval between lung cancer diagnosis and brain metastasis. Conclusions: The pathological subtypes of lung adenocarcinoma-derived brain metastases are associated with patient prognosis. Patients in the poorly differentiated group have worse prognoses compared to those in the moderately to highly differentiated group. Therefore, patients in the poorly differentiated group may require more frequent follow-ups and aggressive treatment.

    Keywords: Invasive lung adenocarcinoma, brain metastasis, Pathological subtype, prognosis, Survival

    Received: 16 May 2024; Accepted: 19 Aug 2024.

    Copyright: © 2024 Zhou, Zhang, Yan, Xie, Tan, Song, Li, Jin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Tianlu Wang, Department of Endoscopy, Liaoning Cancer Hospital and Institute, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.