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REVIEW article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1432900
This article is part of the Research Topic Comprehensive Treatment Strategy for Improving Surgical Resection Rate of Retroperitoneal Sarcomas View all 6 articles

Comprehensive Treatment Strategy for Improving Surgical Resection Rate of Retroperitoneal Sarcomas: A Histology-Specific Approach Narrative Review

Provisionally accepted
Dorian Y. Garcia-Ortega Dorian Y. Garcia-Ortega 1,2*
  • 1 National Institute of Cancerology (INCAN), Mexico City, Mexico
  • 2 Independent researcher, Mexico, Mexico

The final, formatted version of the article will be published soon.

    Retroperitoneal sarcoma (RPS) represents a rare and heterogeneous group of malignancies, posing significant challenges in evaluation and management. Surgery, the cornerstone of RPS treatment, critically depends on complete resection for a favorable prognosis. The extent of resection is a crucial determinant of local control and survival.This review delves into the evolution of multidisciplinary management of localized RPS, highlighting the imperative to adapt surgical strategies to tumor histology, location, and patient functional status. We explore the principles of compartmental surgery-an extended first-line approach that involves resecting adjacent viscera for wide negative margins-and its effectiveness across different histological subtypes of RPS and more limited resections for other types.Particular emphasis is placed on the heterogeneity of the disease, as various histological subtypes exhibit distinct biological behaviors. This necessitates a shift away from a onesize-fits-all treatment approach. The review analyzes the role of different surgical strategies, focusing on histological type and location. Additionally, the potential benefits of (neo)adjuvant treatments, such as radiotherapy and chemotherapy, are examined, recognizing their specific histological indications and limitations.This comprehensive review consolidates recent data on surgical strategies and complementary therapies, advocating for a personalized approach tailored to histology.As understanding of the molecular and genetic underpinnings of RPS continues to evolve, so will strategies for its effective management, underscoring the need for global collaboration among specialists in this field to enhance our collective knowledge and treatment methodologies.

    Keywords: Retroperitoneal sarcoma, Extended resection, Histology-Specific Approach, Reference center, multidisciplinary tumor board (MDTB)

    Received: 14 May 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Garcia-Ortega. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dorian Y. Garcia-Ortega, National Institute of Cancerology (INCAN), Mexico City, Mexico

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.