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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1431629
This article is part of the Research Topic Metastatic Hormone-Sensitive Prostate Cancer: New Therapeutic Strategies to Improve Patient Outcome View all 4 articles

The combination of "HALP score" and time to castration resistance enhances the prognosis prediction in patients with castration-resistant metastatic prostate cancer

Provisionally accepted
İvo Gökmen İvo Gökmen 1*Nazan Demir Nazan Demir 2Pınar Peker Pınar Peker 3Erkan Özcan Erkan Özcan 1Fahri Akgül Fahri Akgül 1İsmail Bayrakçı İsmail Bayrakçı 1Didem Divriklioğlu Didem Divriklioğlu 1Bulent Erdogan Bulent Erdogan 1SERNAZ UZUNOGLU SERNAZ UZUNOGLU 1Muhammed Bekir Hacıoğlu Muhammed Bekir Hacıoğlu 1
  • 1 Trakya University, Edirne, Edirne, Türkiye
  • 2 Sultan I. Murat Public Hospital, Edirne, Türkiye
  • 3 Ege University, Bornova, İzmir, Türkiye

The final, formatted version of the article will be published soon.

    The aim of our study was to assess the impact of the combination of HALP score with TTCR score on OS and PFS in PC patients who developed castration resistance.The study enrolled 152 patients with metastatic disease who had received either ARTAs or docetaxel as first-line treatment. The median cut-off was 30.83 months for the HALP score and 16.1 months for TTCR determined by ROC analysis. Based on these cut-off values, patients were categorized into low-high HALP score and TTCR <16.1 months-TTCR ≥16.1 months groups. The combination of HALP score and TTCR was then stratified by risk into three new groups: Factor 0, Factor 1, and Factor 2.Results: PFS was significantly shorter in the TTCR <16.1 months group compared to the TTCR ≥16.1 months group, as well as in the low-HALP score group compared to the high-HALP score group. Furthermore, as the number of factors increased, a significant increase in OS and PFS was observed in the groups formed by the combination of HALP score and TTCR.We have validated the predictive capability of combining low HALP score (<30.38) and short TTCR (<16.1 months) parameters in estimating the OS and PFS durations of mCRPC patients, both recognized as unfavorable prognostic indicators.

    Keywords: prostate cancer, castration resistance, HALP score, Time to castration resistance, Prognostic tools

    Received: 31 May 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Gökmen, Demir, Peker, Özcan, Akgül, Bayrakçı, Divriklioğlu, Erdogan, UZUNOGLU and Hacıoğlu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: İvo Gökmen, Trakya University, Edirne, 22030, Edirne, Türkiye

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.