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SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1431381
Efficacy and safety of Atractylodes macrocephala-containing traditional Chinese medicine combined with neoadjuvant chemotherapy in the treatment of advanced gastric cancer: a systematic evaluation and meta-analysis
Provisionally accepted
Xiaotao Niu
1
Haoqing Gu
1,2*
Li Jingzhan
1,2
Jiaqian Zuo
1,2
Wenqin Ren
1,2*
YuJie Huang
1,2*
Xinyan Shu
1,2*
Peng Shu
1,2*
Jiang Chao
1,2*- 1 First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
- 2 Department of Medical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China, Nanjing, China
In China, Atractylodes-containing Chinese medicines are widely used as adju vant therapy to neoadjuvant chemotherapy (NAC) in individuals diagnosed with advanced g astric cancer (AGC). Nevertheless, the findings concerning its effectiveness are still restrict ed. The aim from this research was to examine the efficiency and security Atractylodes mac rocephala-containing traditional Chinese medicine together with NAC in the management of AGC.Methods: Literature was systematically searched across 8 electronic databases until Septem ber 20, 2023. Two researchers conducted a thorough review of the selected studies. The pri mary outcome measures included the objective response rate (ORR), disease control rate (D CR), quality of life (QOL), adverse drug reactions (ADRs), and levels of peripheral blood l ymphocytes. The relevant effect estimates are as follows as risk ratios (RR) or mean differe nces (MD) with corresponding 95% confidence intervals (CI). Credibility of information wa s evaluated using the GRADE analyzer.The results showed that solely on the basis of the accessible literature examined in NAC patients, individuals who received the therapeutic regimen containing Atractylodis M acrocephalae Chinese herbal preparations demonstrated a superior overall response rate (Re
Keywords: Atractylodes macrocephala, Neoadjuvant chemotherapy, progressive gastric cancer, Traditional Chinese Medicine, meta-analysis 2.3 Study Selection and Data Extraction
Received: 11 May 2024; Accepted: 18 Sep 2024.
Copyright: © 2024 Niu, Gu, Jingzhan, Zuo, Ren, Huang, Shu, Shu and Chao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haoqing Gu, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Liaoning Province, China
Wenqin Ren, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Liaoning Province, China
YuJie Huang, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Liaoning Province, China
Xinyan Shu, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Liaoning Province, China
Peng Shu, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Liaoning Province, China
Jiang Chao, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Liaoning Province, China
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