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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1430830
This article is part of the Research Topic The Role of the Microbiome in Head and Neck Cancer View all 3 articles
Expression of p16 and Ki67 in laryngeal squamous cell carcinoma and their clinical significance
Provisionally accepted- Department of Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University,Xiamen, China, Xiamen, China
The objective of this study is to assess the prognostic value of Ki67 and p16 proteins in laryngeal cancer.This retrospective cohort analysis comprised 260 patients diagnosed with laryngeal cancer. Immunohistochemistry (IHC) was employed to assess the expression levels of p16 and Ki67, and their correlation with the survival time of laryngeal cancer patients was analyzed.The Ki67 index level exhibited a significant association with the prognosis of laryngeal cancer. Patients with higher Ki67 index levels demonstrated shorter survival times, more severe pathological classification, and higher tumor stages (P < 0.05).Conversely, no significant differences in prognostic characteristics of laryngeal cancer were observed in the p16 (-/+) population (P > 0.05). The median survival times for patients with Ki67 index levels of 0-35%, 36-70%, and 70-100% were 3.54 years, 2.10 years, and 1.92 years, respectively. After adjusting for age, smoking, alcohol consumption, pathological classification, surgical intervention, recurrence, and metastasis, the risk of death for patients with Ki67 index levels of 70-100% was 2.0504 times higher than that of patients with Ki67 index levels of 0-35% (95% CI: 1.2997-3.2345, P = 0.0020).The Ki67 index level is strongly associated with survival time and the risk of death in laryngeal cancer, making it a valuable prognostic indicator. However, the prognostic value of p16 levels in laryngeal cancer is limited. These findings provide important insights for prognosis evaluation and treatment decision-making in patients with laryngeal cancer. 删除了: 74 75 删除了: Background: Laryngeal cancer is a prevalent 76 malignant tumor affecting the head and neck region, and its 77 incidence and mortality rates have been increasing 78 worldwide. Despite advancements in the diagnosis and 79 treatment of laryngeal cancer, the prognosis remains 80 unfavorable. Therefore, there is a critical need to identify 81 novel biomarkers and enhance our understanding of their 82 clinical significance in laryngeal cancer to improve patient 83 prognosis and treatment outcomes.
Keywords: Clinical significance, ki67, Laryngeal squamous cell carcinoma, p16, Laryngeal squamous cell
Received: 10 May 2024; Accepted: 29 Aug 2024.
Copyright: © 2024 Liu, shangguan, Zhang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xue-ying Liu, Department of Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University,Xiamen, China, Xiamen, China
Hanjing shangguan, Department of Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University,Xiamen, China, Xiamen, China
Bing-huang Zhang, Department of Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University,Xiamen, China, Xiamen, China
Xian-yang Luo, Department of Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University,Xiamen, China, Xiamen, China
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