AUTHOR=Rammal Souraya , Semaan Warde , Aprahamian Natalia , Moussallem Romy , Chebly Alain 

TITLE=Spotlight on borderline-IGHV mutational status in chronic lymphocytic leukemia

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1430225

DOI=10.3389/fonc.2024.1430225

ISSN=2234-943X

ABSTRACT=<p>Mutated or unmutated immunoglobulin heavy chain (<italic>IGHV)</italic> gene is an important prognostic factor in chronic lymphocytic leukemia (CLL). However, a small fraction of patients with CLL are classified as borderline (BL)-IGHV. Few data are available on this subgroup of CLL. In this paper, we retrospectively report and analyze data from 21 patients with BL-IGHV CLL, showing the heterogeneity of this subgroup of CLL and paving the way for more research focusing on this entity to optimize the management and treatment of patients with Borderline-IGHV CLL.</p>