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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1429972
This article is part of the Research Topic The Future of Cancer Surveillance Research View all 21 articles

Tobacco- and alcohol-attributable burden of early-onset lip, oral cavity, and pharyngeal Cancer in 204 countries and territories from 1990 to 2019, with projections to 2040

Provisionally accepted
Xingzhu Dai Xingzhu Dai 1Yuanhao Liang Yuanhao Liang 2,3*
  • 1 Guangdong Provincial People's Hospital, Guangzhou, Guangdong Province, China
  • 2 Jiangmen Central Hospital, Jiangmen, Guangdong, China
  • 3 Southern Medical University, Guangzhou, Guangdong, China

The final, formatted version of the article will be published soon.

    Background: Rising trends in early-onset Lip and oral cavity cancer (LOC) and Other pharyngeal cancer (OPC) burden had been observed. This study aimed to evaluate the burdens of LOC and OPC attributable to tobacco and alcohol in young adults aged 15-49 years from 1990 to 2040.: Tobacco-and alcohol-attributable death and disability-adjusted life years (DALYs) for LOC and OPC and the corresponding population-attributable fraction were obtained from Global Burden of Disease Study 2019 for individuals aged 15-49 years. Estimated annual percent change was calculated to quantify the temporal trend of disease burden between 1990 and 2019. The Bayesian age-period-cohort model was used to predict the age-standardized mortality rate from 2020 to 2040. Results: In 2019, an estimated 16,887 deaths and 799,495 DALYs for tobacco-and alcohol-attributable early-onset LOC, and 8,402 deaths and 386,418 DALYs for earlyonset OPC attributable to tobacco and alcohol were reported globally. Despite the global decrease in age-standardized mortality and DALYs rates of tobacco-and alcohol-attributable LOC and OPC in young adults aged 15-49 years between 1990 and 2019, certain regions experienced increases, such as regions of Asia, Eastern Europe, and Western Sub-Saharan Africa. Moreover, a growing age-standardized mortality in individuals aged <34 years was found. The socio-demographic index level was positively associated with a faster reduction of early-onset LOC and OPC DALYs attributable to alcohol use and smoking, except for that due to chewing tobacco.Furthermore, projections have also indicated an expected increase in the age-standardized mortality for tobacco-and alcohol-attributable early-onset LOC and OPC.Conclusions: Significant regional and demographic disparities in tobacco and alcoholrelated early-onset LOC and OPC burden and their attributable proportion highlight a need for tailored age-and region-appropriate interventions to reduce the future LOC and OPC burden among young adults.

    Keywords: Early-onset, lip and oral cavity cancer, Other pharyngeal cancer, burden of disease, Risk factors, estimated annual percentage change

    Received: 09 May 2024; Accepted: 24 Sep 2024.

    Copyright: © 2024 Dai and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuanhao Liang, Jiangmen Central Hospital, Jiangmen, 529030, Guangdong, China

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