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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1428942
This article is part of the Research Topic Recent Advances in Liquid Biopsy in Colorectal Cancer: Vol II View all 6 articles

Bibliometric Analysis of Global Research Trends and Prospects on Circulating Tumor DNA for Colorectal Cancer

Provisionally accepted
Jing Pang Jing Pang Pengyu Bai Pengyu Bai *Yong Zhang Yong Zhang *Lichun Wang Lichun Wang *
  • Shanxi Provincial Cancer Hospital, Taiyuan, China

The final, formatted version of the article will be published soon.

    Background: Colorectal cancer (CRC) is one of the most commonly diagnosed advanced-stage malignancies worldwide, placing a substantial burden on both the economic and social development of numerous countries.Objective: This manuscript aims to synthesize the existing evidence and explore potential avenues for future scholarly research on ctDNA in colorectal cancer.Methods: Bibliometric analyses were performed using the bibliometrix package in R, along with CiteSpace and VOSviewer software. The search was restricted to publications up to March 31, 2024, using the following terms: ("ctDNA" OR "circulating tumor DNA") AND ("colorectal cancer" OR "colorectal tumor") from the Web of Science Core Collection (WoSCC) database.Results: Ultimately, we identified 1,310 documents published in 353 journals authored by 7,683 researchers from 2,417 institutions across 66 countries. The United States was the most productive country. The Journal of Clinical Oncology was the most prolific, publishing 111 articles with 3,396 citations. The top five keywords were "colorectal cancer," "circulating tumor DNA," "acquired resistance," "cell-free DNA," and "plasma." The top five cluster labels for references were "advanced cancer," "metastatic colorectal cancer," "liquid biopsy," "colorectal cancer," and "human colorectal cancer xenograft."The collaborative networks are primarily composed of highly productive authors, prestigious institutions, and leading countries. Additionally, the advancement of detection technologies, the development of standardized protocols, the exploration of circulating tumor DNA (ctDNA) dynamics in colorectal cancer (CRC), and the implementation of large-scale clinical trials for ctDNA-guided precision therapy in CRC are expected to become major research priorities in the future.

    Keywords: circulating tumor DNA, colorectal cancer, CtDNA, bibliometric analysis, CRC

    Received: 07 May 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Pang, Bai, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Pengyu Bai, Shanxi Provincial Cancer Hospital, Taiyuan, China
    Yong Zhang, Shanxi Provincial Cancer Hospital, Taiyuan, China
    Lichun Wang, Shanxi Provincial Cancer Hospital, Taiyuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.