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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1428918

Germline BRCA 2 mutation in primary peritoneal carcinoma: a rare malignancy

Provisionally accepted
Yan-Ying Huang Yan-Ying Huang 1*Yue Zhang Yue Zhang 1Wen-Jun Xie Wen-Jun Xie 2Zhao-Dong Li Zhao-Dong Li 1
  • 1 Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, China
  • 2 Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Background: Primary peritoneal carcinoma (PPC) is a rare malignancy. Clinically, its histological morphology resembles that of epithelial ovarian tumors (EOC), often leading to misdiagnosis. Diagnosis and treatment of PPC are time-sensitive because of the rapidly progressive nature of the disease. Case Report: Herein, we report the case of a 54-year-old woman who was initially diagnosed with ovarian cancer; however, extensive workup showed evidence of Müllerian PPC origin. Furthermore, the patient harbored a targetable BRCA mutation. Conclusion: The patient was treated with the BRCA-targeting agents and had a good prognosis after surgery.

    Keywords: Primary peritoneal carcinoma, CA125, Epithelial ovarian tumor, BRCA 2, PARP

    Received: 07 May 2024; Accepted: 15 Aug 2024.

    Copyright: © 2024 Huang, Zhang, Xie and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yan-Ying Huang, Hangzhou Red Cross Hospital, Hangzhou, 310004, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.