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MINI REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1428583
This article is part of the Research Topic Organ Preservation for Rectal Cancer Patients View all 5 articles

Enhancing Clinical Complete Response Assessment in Rectal Cancer: Integrating Transanal Multipoint Full-Layer Puncture Biopsy Criteria: A systematic review

Provisionally accepted
Xin Liu Xin Liu Ruibin Liu Ruibin Liu Mengying Zhu Mengying Zhu Guohua Zhao Guohua Zhao Yue Wang Yue Wang *
  • Liaoning Cancer Hospital, China Medical University, Shenyang, China

The final, formatted version of the article will be published soon.

    There is currently a lack of standardized criteria for evaluating clinical complete response (cCR) in rectal cancer post-neoadjuvant chemoradiotherapy (nCRT), often resulting in discrepancies with true pathological complete response (pCR). Staging local lesions via MRI is challenged by tissue edema and fibrosis post-nCRT, while endoscopic biopsy accuracy is compromised by residual cancer foci in the muscular layer. Transanal local excision offers a relatively accurate assessment of lesion regression but poses challenges including impaired anal function and elevated complication rates.Building on current diagnostic frameworks, we propose enhancing cCR assessment by integrating histological criteria from transanal multipoint full-layer puncture biopsy (TMFP). This approach aims to improve accuracy while minimizing complications, offering promise for patients opting for observation-based treatments. Further research is needed for definitive conclusions.

    Keywords: Rectal Neoplasms, Neoadjuvant Therapy, clinical complete response, Watch and wait strategy, Local resection

    Received: 06 May 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Liu, Liu, Zhu, Zhao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yue Wang, Liaoning Cancer Hospital, China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.