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REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1428464
This article is part of the Research Topic Toward the Future Management of Patients with Chronic Lymphocytic Leukemia View all 3 articles
MANAGEMENT OF INFECTIONS FOR PATIENT TREATED WITH IBRUTINIB IN CLINICAL PRACTICE
Provisionally accepted- 1 Independent researcher, Pisa, Tuscany, Italy
- 2 Hematology Clinic, Marche University Hospital, Ancona, Italy
- 3 Dipartimento di Ematologia, Ospedale universitario di Siena, Siena, Tuscany, Italy
- 4 Mazzoni Hospital, Ascoli Piceno, Italy
- 5 Azienda Ospedaliera Santa Maria Terni, Terni, Italy
- 6 Hematology and Stem Cell Transplant Center, AORMN Hospital, Pesaro, Italy
- 7 Careggi University Hospital, Florence, Italy
- 8 University of Perugia, Perugia, Italy
Ibrutinib, a highly effective inhibitor of the Bruton tyrosine kinase, has significantly transformed the therapeutic approach in chronic lymphocytic leukemia (CLL). Despite these advancements, the disease continues to be characterized by immune dysfunction and increased susceptibility to infections, with mortality rates from infections showing no significant improvement over the past few decades. Therefore, timely prevention, recognition, and treatment of infections remains an important aspect of the standard management of a patient with CLL. A panel of hematologists with expertise in CLL met to discuss existing literature and clinical insights for the management of infectious in CLL undergoing ibrutinib treatment. Despite not being a fully comprehensive review on the topic, this work provides a set of practical recommendations that can serve as a guide to healthcare professionals who manage these patients in their daily clinical practice.
Keywords: CLL, Ibrutinib, Infection, Recommendation, prophylaxis
Received: 06 May 2024; Accepted: 23 Aug 2024.
Copyright: © 2024 Baratè, Scortechini, Ciofini, Picardi, Ageletti, Loscocco, Sanna, Isidori and SPORTOLETTI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Alessandro Sanna, Careggi University Hospital, Florence, Italy
PAOLO SPORTOLETTI, University of Perugia, Perugia, Italy
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