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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1428142
Life-style and metabolic factors affect risk for meningioma in women: A prospective population-based study (The Cohort of Norway)
Provisionally accepted- 1 Emergency Clinical Hospital Bagdasar Arseni, Bucharest, Romania
- 2 University of Oslo, Oslo, Oslo, Norway
- 3 Oslo University Hospital, Oslo, Norway
- 4 Cancer Registry of Norway, Oslo, Norway
Meningioma is the most common primary brain tumor, with a clear preponderance for women. Obesity is considered a risk factor for development of meningioma. Obesity is also the clinical hallmark of metabolic syndrome, characterized by glucose intolerance, dyslipidemia and hypertension. Life style and metabolic factors directly impact on overweight and obesity and are therefore potential risk factors for meningioma development. The aim of this study is to assess life-style and metabolic factors for meningioma risk in women.: The Cohort of Norway (CONOR) is a nationwide health survey, conducted between 1994 and 2003, including anthropometric measures, blood tests and health questionnaires. Linkage to the National Cancer Registry enabled identification of intracranial meningioma during follow-up until December 2018.Results: 81 652 women were followed for a total of 1.5 million years and 238 intracranial meningiomas were identified. Increasing level of physical activity (HR 0.81; 95% CI 0.68-0.96; p trend <0.02) and parity (HR 0.83; 95% CI 0.71-0.97; p trend <0.03) were negatively associated with meningioma risk. Diabetes mellitus or glucose intolerance increased the risk for meningioma (HR 2.54; 95% CI 1.60-4.05). Overweight and obesity were not associated with meningioma risk, neither was metabolic syndrome. However, participants without metabolic dysfunction had a reduced meningioma risk, while participants with all 5 metabolic factors present, had a 4-fold risk increase for meningioma (HR 4.28;).Life-style factors seem to influence meningioma risk significantly. However, detangling the complex associations and interactions between factors for meningioma risk will be a challenging task for future studies.
Keywords: Meningioma, metabolic syndrome, Parity, diabetes, Obesity, brain tumor, risk factor, Smoking
Received: 05 May 2024; Accepted: 24 Jul 2024.
Copyright: © 2024 Gheorghiu, Brunborg, Johannesen, Helseth, Zwart and Wiedmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Markus K. Wiedmann, Oslo University Hospital, Oslo, Norway
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