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CASE REPORT article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1425809

Case Report: A Rare Clinical Presentation of a Difficult Diagnosis of Dedifferentiated Liposarcoma Showing Leiomyosarcoma Phenotype in the Ileocecal Region

Provisionally accepted
Tomonori Kawasaki Tomonori Kawasaki 1Tomoaki Tashima Tomoaki Tashima 1Kojiro Onohara Kojiro Onohara 2Yasumitsu Hirano Yasumitsu Hirano 1Suguru Shirotake Suguru Shirotake 1Tomoaki Torigoe Tomoaki Torigoe 1Yasuo Yazawa Yasuo Yazawa 1Masataka Hirasaki Masataka Hirasaki 1Masanori Wako Masanori Wako 3Taro Fujimaki Taro Fujimaki 3Jiro Ichikawa Jiro Ichikawa 3*
  • 1 Saitama Medical University International Medical Center, Hidaka, Saitama, Japan
  • 2 Department of Radiology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
  • 3 Department of Orthopedic Surgery, University of Yamanashi, Yamanashi, Japan

The final, formatted version of the article will be published soon.

    Dedifferentiated liposarcoma is a malignant lipomatous tumor that rarely occurs in the gastrointestinal tract, including the ileocecal region. In this case, computed tomography and magnetic resonance imaging showed no fatty mass located in the mesenteric or submucosal lesion, and positron emission tomography-computed tomography showed a high maximum standardized uptake value, collectively indicating the gastrointestinal stroma tumor and lymphoma. The pathological findings resemble leiomyosarcoma, the immunohistochemistry findings including mouse double minute 2 homolog and cyclin D-dependent kinase-4, and amplification of mouse double minute 2 homolog in fluorescence in situ hybridization just favored the diagnosis of dedifferentiated liposarcoma with leiomyosarcoma phenotype and not leiomyosarcoma. Recently, a new inhibitor for mouse double minute 2 homolog and cyclin Ddependent kinase-4 has been developed, and clinical trials for dedifferentiated liposarcoma are currently ongoing. This could change the treatment strategy drastically compared with other soft tissue sarcomas. Hence, a correct diagnosis for dedifferentiated liposarcoma is required.

    Keywords: Dedifferentiated liposarcoma, imaging, Immunohistochemistry, Leiomyosarcoma, Gastrointestinal stroma tumor

    Received: 26 Jun 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Kawasaki, Tashima, Onohara, Hirano, Shirotake, Torigoe, Yazawa, Hirasaki, Wako, Fujimaki and Ichikawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiro Ichikawa, Department of Orthopedic Surgery, University of Yamanashi, Yamanashi, Japan

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