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SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1425078
This article is part of the Research Topic Emerging Fast Medical Imaging Techniques in Radiology View all articles
Radiomics Based on MRI in Predicting Lymphovascular Space Invasion of Cervical Cancer: A Meta-analysis
Provisionally accepted- 1 Department of Radiology, Tongren People's Hospital,, Tongren, China
- 2 Department of Radiology, Wanshan District People's Hospital,, Tongren, China
The objective of this meta-analysis is to assess the efficacy of radiomics techniques utilizing Magnetic Resonance Imaging (MRI) for predicting Lymphovascular Space Invasion (LVSI) in patients with Cervical Cancer (CC).Methods: A comprehensive literature search was conducted in databases including PubMed, Embase, Cochrane Library, Medline, Scopus, CNKI, and Wanfang, with studies published up to April 8, 2024, being considered for inclusion. The meta-analysis was performed using Stata 15 and Review Manager 5.4. The quality of the included studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 and Radiomics Quality Score tools. The analysis encompassed the pooled sensitivity, specificity, Positive Likelihood Ratio (PLR), Negative Likelihood Ratio (NLR), and Diagnostic Odds Ratio (DOR). Summary ROC curves were constructed, and the AUC was calculated. Heterogeneity was investigated using meta-regression. Statistical significance was set at P ≤ 0.05. Results: Thirteen studies involving a total of 2,245 patients were included in the meta-analysis. The overall sensitivity and specificity of the MRI-based model in the Training set were 83% (95%CI: 77%-87%) and 72% (95%CI: 74%-88%), respectively. The AUC, DOR, PLR, and NLR of the MRI-based model in the Training set were 0.89 (95%CI: 0.86-0.91), 22 (95%CI: 12-40), 4.6 (95%CI: 3.1-7.0), and 0.21 (95%CI: 0.16-0.29), respectively. Subgroup analysis revealed that the AUC of the model combining radiomics with clinical factors [0.90 (95%CI: 0.87-0.93)] was superior to models based on T2-weighted Imaging (T2WI) sequence [0.78 (95%CI: 0.74-0.81)], contrast-enhanced T1-weighted Imaging (T1WI-CE) sequence [0.85 (95%CI: 0.82-0.88)], and multiple sequences [0.86 (95%CI: 0.82-0.89)] in the Training set. The pooled sensitivity and specificity of the model integrating radiomics with clinical factors [83% (95%CI: 73%-89%) and 86% (95%CI: 73%-93%)] surpassed those of models based on T2WI sequence [79% (95%CI:71%-85%) and 72% (95%CI: 67%-76%)], T1WI-CE sequence [78% (95%CI: 67%-86%) and 78% (95%CI: 68%-86%)], and multiple sequences [78% (95%CI: 67%-87%) and 79% (95%CI: 2 70%-87%)], respectively. Funnel plot analysis indicated an absence of publication bias (P > 0.05).LVSI in CC patients. The diagnostic performance of models combing radiomics and clinical factors is superior to that of models utilizing radiomics alone.
Keywords: cervical cancer, Radiomics, Magnetic Resonance Imaging, Systematic review, Lymphovascular space invasion
Received: 29 Apr 2024; Accepted: 26 Sep 2024.
Copyright: © 2024 Yang, Wu, Zhang, Qian, Fu, Yang, Luo, Qin and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Min Wu, Department of Radiology, Tongren People's Hospital,, Tongren, China
Jiancheng Zhang, Department of Radiology, Tongren People's Hospital,, Tongren, China
Hongwei Qian, Department of Radiology, Tongren People's Hospital,, Tongren, China
Xiangyang Fu, Department of Radiology, Tongren People's Hospital,, Tongren, China
Jing Yang, Department of Radiology, Tongren People's Hospital,, Tongren, China
Yingbin Luo, Department of Radiology, Tongren People's Hospital,, Tongren, China
Zhihong Qin, Department of Radiology, Tongren People's Hospital,, Tongren, China
Tianliang Shi, Department of Radiology, Tongren People's Hospital,, Tongren, China
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