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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1423118

The correlation between vaginal pathogens and high-risk human papilloma virus infection: A meta-analysis of case-control studies

Provisionally accepted
Jun Yang Jun Yang 1Xin Long Xin Long 2Min Zhou Min Zhou 2*Li-Na Hu Li-Na Hu 1*
  • 1 Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • 2 Chongqing Health Center for Women and Children, Chongqing, Chongqing, China

The final, formatted version of the article will be published soon.

    Systematic study on the relationship between vaginal microbiota and high-risk human papillomavirus infection (HR-HPV) is limited. Hence, the aim of this study is to investigate the correlation between vaginal microbiota and HR-HPV infection through a meta-analysis of case-control studies. Chinese Journal Full-text database, Wanfang database, PubMed database, VIP Chinese Science and Technology Journal database, Web of Science, ScienceDirect, ProQuest, JSTOR, Wiley, and IEEE Xplore were synthetically searched for studies about the correlation between vaginal microbiota and HR-HPV infection. Revman 5.3 software was used to assess the relationship between vaginal microbiota and HPV infection through meta-analysis. Finally, forest map was used to calculate the results and funnel plot was applied to test the publication bias. Fourteen independent studies were admitted in this study, containing a total of 21, 446 women in gynecological outpatients. Compared with HR-HPV negative group, the prevalence of bacterial vaginosis (BV) (odds ratio (OR)=2.45, 95% confidence intervals (CI): 1.83-3.27, P<0.00001), Ureaplasma urealyticum (UU) (OR=1.38, 95% CI: 1.23-1.54, P<0.00001), and Chlamydia trachomatis (CT) (OR=3.53, 95% CI: 2.82-4.41, P<0.00001) increased in HR-HPV positive group through meta-analysis, while, there was no significant difference in the prevalence of trichomonal vaginitis (TV) (OR=1.69, 95% CI: 0.97-2.96, P=0.06) and vulvovaginal candidiasis (VVC) (OR=0.91, 95% CI: 0.54-1.51, P=0.71. Vaginal pathogens are closely related to HR-HPV infection. When BV, UU, and CT are abnormal, the risk of HR-HPV infection is increased.

    Keywords: HR-HPV, vaginal microbiota, Vaginal pathogens, bacterial vaginosis, Vaginal Infection, Meta-analysis

    Received: 17 May 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Yang, Long, Zhou and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Min Zhou, Chongqing Health Center for Women and Children, Chongqing, 400065, Chongqing, China
    Li-Na Hu, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.