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REVIEW article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1422623

Predicting Lymph Node Metastasis of Clinical T1 Non-small Cell Lung Cancer:a brief review of possible methodologies and controversies

Provisionally accepted
Li Zhang Li Zhang 1,2*Feiyue Zhang Feiyue Zhang 3Gaofeng Li Gaofeng Li 4Xudong Xiang Xudong Xiang 4Haifeng Liang Haifeng Liang 2Yan Zhang Yan Zhang 2
  • 1 Kunming Medical University, Kunming, China
  • 2 the Fifth Affiliated Hospital of Kunming Medical University, Gejiu City, China
  • 3 People's Hospital of Yuxi City, Yuxi, China
  • 4 Yunnan Cancer Hospital, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer and poses a serious threat to human health. Due to the advances in lung cancer screening, more and more clinical T1 NSCLC defined as a tumor with a maximum diameter of 3cm surrounded by lung tissue or visceral pleura have been detectedand have achieved favorable treatment outcomes, greatly improving the prognosis of NSCLC patients.However, the preoperative lymph node staging and intraoperative lymph node dissection patterns of operable clinical T1 NSCLC are still subject to much disagreement, as well as the heterogeneity between primary tumors and metastatic lymph nodes poses a challenge in designing effective treatment strategies. This article comprehensively describes the clinical risk factors of clinical T1 NSCLC lymph node metastasis, and its invasive and non-invasive prediction, focusing on the genetic heterogeneity between the primary tumor and the metastatic lymph nodes, which is significant for a thoroughly understanding of the biological behavior of early-stage NSCLC.

    Keywords: clinical T1 non-small cell lung cancer, lymph node metastasis, Lymph node dissection, Noninvasive prediction, heterogeneity

    Received: 24 Apr 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Zhang, Zhang, Li, Xiang, Liang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li Zhang, Kunming Medical University, Kunming, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.