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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1422006

Progression of Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia in a Woman with Lynch Syndrome: A Case Report and Review of the Literature

Provisionally accepted
YaTing Hsu YaTing Hsu CHI-HAU CHEN CHI-HAU CHEN *
  • National Taiwan University Hospital, Taipei, Taiwan

The final, formatted version of the article will be published soon.

    Endometrial cancer in Lynch syndrome is characterized by a higher incidence, younger age at onset, and increased recurrence rates compared to sporadic cases, while the safety and efficacy of fertility-sparing treatments remain uncertain. This case report presents the oncology outcome of fertility-preserving treatment in a 39-year-old woman diagnosed with Lynch syndrome and atypical endometrial hyperplasia. Initially, she responded favorably to fertility-preserving treatment but subsequently experienced disease relapse and rapid progression during retreatment. Final pathology revealed endometrial cancer with metastasis to the right ovary, categorized as FIGO 2023 stage IIIA1. This population's unique molecular mechanisms and genetic mutations warrant special consideration when opting for fertility-sparing treatment. We have reviewed and summarized the oncology and pregnancy outcomes among Lynch syndrome and MMR-deficient patients through previous literature. However, no studies have investigated retreatment after recurrence in Lynch syndrome. Our case highlights the potential risks associated with retreatment following relapse. Vigilant monitoring and prompt consideration of surgical intervention are recommended upon disease relapse.

    Keywords: Lynch Syndrome, fertility-sparing treatment, Atypical endometrial hyperplasia, endometrial cancer, oncology outcome

    Received: 23 Apr 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Hsu and CHEN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: CHI-HAU CHEN, National Taiwan University Hospital, Taipei, Taiwan

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