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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Breast Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1421425
This article is part of the Research Topic Breast Imaging for Computer Aided Diagnosis View all articles

A multi-centre, randomised trial for diagnostic efficacy of the automatic breast volume scanner ultrasound for breast cancer screening in China Short title: Diagnostic efficacy of the automatic breast volume scanner ultrasound for breast cancer screening

Provisionally accepted
Ying Xu Ying Xu Yali Xu Yali Xu Songjie Shen Songjie Shen Yidong Zhou Yidong Zhou Feng Mao Feng Mao Yan Lin Yan Lin Xiaohui Zhang Xiaohui Zhang Yanna Zhang Yanna Zhang Qiang Sun Qiang Sun *
  • Peking Union Medical College Hospital (CAMS), Beijing, China

The final, formatted version of the article will be published soon.

    The US plays a crucial role in screening Asian women for breast disease. ABUS offers several advantages over traditional HHUS, including quicker examination, objectivity, and the ability to store and reconstruct images. This study marks the first large-scale opportunistic screening of ABUS in the population. Between January 1, 2016, and December 31, 2019, 10,537 women aged 35-75 years from nine districts were randomly assigned to either HHUS or ABUS groups. Diagnostic methods were quantified, and comparisons were made using the Chi-square test. The screening groups consisted of 5,445 participants for HHUS and 4,936 for ABUS. The HHUS and ABUS groups identified 90 carcinomas and 292 benign lesions or 71 carcinomas and 178 benign lesions, respectively. SE), SP, AC, PPV, and NPV for HHUS were 51.11%, 93.84%, 93.13%, 12.23%, and 99.13%, respectively, while for ABUS, they were 66.20%, 93.77%, 93.38%, 13.43%, and 98.98%. The area under the curve (AUC) values for HHUS and ABUS were 0.72 (95% CI: 0.67-0.78) and 0.86 (95% CI: 0.82-0.91), respectively, indicating superior diagnostic performance of ABUS over HHUS (Delong test p < 0.05). ABUS is user-friendly, requires minimal training, reduces reliance on examiner experience, and demonstrates potential for superior sensitivity compared to HHUS in breast cancer screening.

    Keywords: breast cancer, breast screening, ABUS, HHUS, ultrasound

    Received: 22 Apr 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Xu, Xu, Shen, Zhou, Mao, Lin, Zhang, Zhang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qiang Sun, Peking Union Medical College Hospital (CAMS), Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.