AUTHOR=Sun Yaquan , Jiang Wei , Liao Xiang , Wang Dongqing 

TITLE=Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1421067

DOI=10.3389/fonc.2024.1421067

ISSN=2234-943X

ABSTRACT=<p>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.</p>