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REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1421067

Hallmarks of Perineural Invasion in Pancreatic Ductal Adenocarcinoma: new biological dimensions

Provisionally accepted
Yaquan Sun Yaquan Sun 1Wei Jiang Wei Jiang 1Xiang Liao Xiang Liao 2*Dongqing Wang Dongqing Wang 2*
  • 1 Jiangsu University, Zhenjiang, Jiangsu Province, China
  • 2 Affiliated Hospital of Jiangsu University, Zhenjiang, China

The final, formatted version of the article will be published soon.

    Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment.In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.

    Keywords: Pancreatic Ductal Adenocarcinoma, Perineural invasion, Tumor Microenvironment, neural reprogramming, pain 64

    Received: 21 Apr 2024; Accepted: 01 Jul 2024.

    Copyright: © 2024 Sun, Jiang, Liao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiang Liao, Affiliated Hospital of Jiangsu University, Zhenjiang, China
    Dongqing Wang, Affiliated Hospital of Jiangsu University, Zhenjiang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.