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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cardio-Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1420333

Increased risk of cardiovascular disease among kidney cancer survivors: a nationwide population-based cohort study

Provisionally accepted
Minji Jung Minji Jung 1*Eunjung Choo Eunjung Choo 2Shufeng Li Shufeng Li 1Zhengyi Deng Zhengyi Deng 1Jinhui Li Jinhui Li 1Mingyi Li Mingyi Li 1Satvir Basran Satvir Basran 1Sukhyang Lee Sukhyang Lee 2Marvin Langston Marvin Langston 3Benjamin Chung Benjamin Chung 1
  • 1 Department of Urology, Stanford University Medical Center, Stanford, United States
  • 2 Department of Clinical Pharmacy, College of Pharmacy, Ajou University, Suwon, Republic of Korea
  • 3 Department of Epidemiology and Population Health, Stanford University Medical Center, Stanford, United States

The final, formatted version of the article will be published soon.

    Background: Cardiovascular disease (CVD) is a major concern of morbidity and mortality among cancer survivors. However, few evidence exists on the short-and long-term risk of CVD in kidney cancer (KCa) survivors.In this nationwide, large population-based retrospective cohort study, we used the Korean national health insurance and medical checkup survey linkage database (2007-2021), drawn from the entire Korean population. We included adults diagnosed with KCa as the first primary cancer and matched them to an individual without KCa at a 1:5 ratio. The primary outcome was CVD incidence, including myocardial infarction, stroke, atrial fibrillation, heart failure, peripheral arterial occlusion, and venous thromboembolism (VTE). We evaluated CVD risk at 6 months, 1 year, and 5 years following cancer diagnosis, using Fine-Gray competing risk models that accounted for death as a competing factor.Results: A total of 149,232 participants were included (KCa survivors: N=20,093 and matched non-KCa individuals: N=129,139). After 6-month follow-up, KCa survivors showed an increased risk of CVD compared to the general population (subdistribution hazard ratio (HR) 2.70, 95% confidence interval (CI) 2.31-3.15). After 1 year, KCa survivors had a higher risk of CVD (HR=1.77, 95% CI: 1.56-2.00). After 5 years, this elevated CVD risk remained (HR=1.10, 95% CI: 1.03-1.18), with VTE identified as the primary contributing disease (HR=3.05, 95% CI:2.59-3.59).KCa survivors had an increased risk of CVD up to 5 years after cancer diagnosis compared to the general population. Our findings emphasize the importance of comprehensive healthcare management for both CVD and KCa throughout cancer survivorship.

    Keywords: Kidney cancer, cardiovascular disease, cancer survivorship, Primary Prevention, Cardiooncology

    Received: 19 Apr 2024; Accepted: 26 Jun 2024.

    Copyright: © 2024 Jung, Choo, Li, Deng, Li, Li, Basran, Lee, Langston and Chung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Minji Jung, Department of Urology, Stanford University Medical Center, Stanford, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.