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CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1417776

Case report: metastatic melanoma derived from a somatic-type malignant transformation of a mediastinal teratoma treated with immune checkpoint inhibitors

Provisionally accepted
Roberto Rosenfeld Roberto Rosenfeld Silvia Riondino Silvia Riondino *Giusy Parisi Giusy Parisi Rexhina Ajdhoni Rexhina Ajdhoni Francesco Torino Francesco Torino Sabrina Mariotti Sabrina Mariotti Mario Roselli Mario Roselli
  • Department of Systems Medicine, Faculty of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy

The final, formatted version of the article will be published soon.

    Teratomas are germ cell tumors (GCTs) consisting of tissues derived from more than one primitive germ cell layers. The treatment of patients affected by a teratoma with somatic-type malignancy (STM) is challenging, since they are characterized by a poor prognosis, due to chemoresistance to standard cisplatin-based regimens. There is large disagreement in literature on the best treatment to be administered for SMTs, whether a GCTs-oriented therapy or an SMT-oriented one. Only five more case reports were described for melanomatous STM and for which there's no data available for efficacy evidences of immune checkpoint inhibitors in this setting. Here we report the case of a patient with an initial diagnosis of mediastinal pure seminoma at the first biopsy. After four cycles of a standard cisplatin-based regimen and a partial response, a radical surgery was performed, revealing a mediastinal teratoma with triple STM component (melanoma, leiomyoarcoma and primitive neuroectodermal tumor).

    Keywords: Data curation, Writing -review & editing. Mario Roselli: Supervision, Writing -review & editing. Rexhina Ajdhoni: Data curation, Writing -review & editing. Roberto Rosenfeld: Conceptualization, methodology, Writing -original draft, Writing -review & editing. Sabrina Mariotti: Data curation, Writing -review & editing. Silvia Riondino: Conceptualization

    Received: 15 Apr 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Rosenfeld, Riondino, Parisi, Ajdhoni, Torino, Mariotti and Roselli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Silvia Riondino, Department of Systems Medicine, Faculty of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy

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